Saccharine, Aspartame, and sucralose
I came across two articles recently from the same authors in different scientific journals about how the consumption of the three most commonly used non-caloric artificial sweeteners — saccharin, sucralose and aspartame (Sweet-n-Low, Equal & Splenda)— directly induces a propensity for obesity and glucose intolerance in mice AND people, by changing the gut microbiome in a way that leads to absorption of more calories.
This is the abstract of the article from the Nature magazine (online edition):
"Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial.
Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota.
We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects.
Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage."
And this is Seth Bilazarian, MD's insight:
"We have been using non-caloric artificial sweeteners for more than a century. Today the food industry is using them in ever-greater quantities in 'diet' foodstuffs and they are recommended for weight loss and for individuals with glucose intolerance and type 2 diabetes mellitus. This report shows that the three most commonly used non-caloric artificial sweeteners: saccharin, sucralose and aspartame change the gut microbiome in a way that leads to absorption of more calories and that compromises glucose tolerance."
Isn't it high time to develop new nutritional strategies tailored to the maintenance of healthy gut microbiota? Just like what SUGARLESSe™ offers?
This is the abstract of the article from the Nature magazine (online edition):
"Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial.
Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota.
We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects.
Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage."
And this is Seth Bilazarian, MD's insight:
"We have been using non-caloric artificial sweeteners for more than a century. Today the food industry is using them in ever-greater quantities in 'diet' foodstuffs and they are recommended for weight loss and for individuals with glucose intolerance and type 2 diabetes mellitus. This report shows that the three most commonly used non-caloric artificial sweeteners: saccharin, sucralose and aspartame change the gut microbiome in a way that leads to absorption of more calories and that compromises glucose tolerance."
Isn't it high time to develop new nutritional strategies tailored to the maintenance of healthy gut microbiota? Just like what SUGARLESSe™ offers?
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